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Article

rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome.

The Journal of biological chemistry - 13 Jan 2006

Ceresa Brian P, Bahr Steven J

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase family. Ligand (epidermal growth factor or EGF) binding to the EGFR results in the coordinated activation and integration of biochemical signaling events to mediate cell growth, migration, and differentiation. One mechanism the cell utilizes to orchestrate these events is ligand-mediated endocytosis through the canonical...

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Share to Adenoviridae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16282324
DOI: 10.1074/jbc.M504175200

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome.PMID 16282324Read ↗

Approaches to analyze the role of Rab GTPases in endocytic trafficking of epidermal growth factor receptor (EGFR).Semantic proximity Read ↗

Expression of dominant negative rab5 in HeLa cells regulates endocytic trafficking distal from the plasma membrane.Semantic proximity Read ↗

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activitySemantic proximity Read ↗

Continual expression of Rab5(Q79L) causes a ligand-independent EGFR internalization and diminishes EGFR activity.Semantic proximity Read ↗

ARF promotes the degradation of the Epidermal Growth Factor Receptor by the lysosome.Semantic proximity Read ↗

Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor familySemantic proximity Read ↗

RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans.Semantic proximity Read ↗

Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis.Semantic proximity Read ↗

The rab7 GTPase resides on a vesicular compartment connected to lysosomes.Semantic proximity Read ↗

Gab1 signaling is regulated by EGF receptor sorting in early endosomes.Semantic proximity Read ↗

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Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a.Semantic proximity Read ↗

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