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Article

Mechanisms elevating ORMDL3 expression in recurrent wheeze patients: role of Ets-1, p300 and CREB.

The international journal of biochemistry & cell biology - 1 Jul 2012

Jin Rui, Xu Hua-Guo, Yuan Wen-Xiao, Zhuang Li-Li, Liu Li-Fei, Jiang Li, Zhu Liang-Hua, Liu Jia-Yin, Zhou Guo-Ping

Abstract excerpt

The first genetic factor identified for childhood asthma by genome-wide association study (GWAS) is the locus on chromosome 17q21, harboring the Orosomucoid 1-like 3 (ORMDL3) gene. ORMDL3 is implicated in facilitation of endoplasmic reticulum-mediated inflammatory responses, believed to underlie its association with asthma. In the present study, we demonstrated that mRNA expression of ORMDL3 is significantly...

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Identifiers

PMID: 22546552
DOI: 10.1016/j.biocel.2012.04.007

Genes

ORMDL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Mechanisms elevating ORMDL3 expression in recurrent wheeze patients: role of Ets-1, p300 and CREB.PMID 22546552Read ↗

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A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.Semantic proximity Read ↗

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