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Article

Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze.

Genes and immunity - 1 Jan 2012

Bräuner E V, Loft S, Raaschou-Nielsen O, Vogel U, Andersen P S, Sørensen M

Abstract excerpt

The first common genetic factor identified for pediatric asthma by genome-wide association is the chromosome 17q21 locus, harbouring the ORMDL3 gene. ORMDL3 is involved in facilitation of endoplasmic reticulum-mediated inflammatory responses, believed to underlie its asthma association. We investigated associations between the rs7216389 polymorphism in the 17q21 locus affecting ORMDL3 expression and the risk for...

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Source

Identifiers

PMID: 21796154
DOI: 10.1038/gene.2011.51

Genes

ORMDL3

Provenance

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