Article
Association of ORMDL3 with rhinovirus-induced endoplasmic reticulum stress and type I Interferon responses in human leucocytes.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Mar 2017
Liu Y-P, Rajamanikham V, Baron M, Patel S, Mathur S K, Schwantes E A, Ober C, Jackson D J, Gern J E, Lemanske R F, Smith J A
Abstract excerpt
BACKGROUND: Children with risk alleles at the 17q21 genetic locus who wheeze during rhinovirus illnesses have a greatly increased likelihood of developing childhood asthma. In mice, overexpression of the 17q21 gene ORMDL3 leads to airway remodelling and hyperresponsiveness. However, the mechanisms by which ORMDL3 predisposes to asthma are unclear. Previous studies have suggested that ORMDL3 induces endoplasmic...
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