Article
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
Nature genetics - 1 Jan 2014
Bønnelykke Klaus, Sleiman Patrick, Nielsen Kasper, Kreiner-Møller Eskil, Mercader Josep M, Belgrave Danielle, den Dekker Herman T, Husby Anders, Sevelsted Astrid, Faura-Tellez Grissel, Mortensen Li Juel, Paternoster Lavinia, Flaaten Richard, Mølgaard Anne, Smart David E, Thomsen Philip F, Rasmussen Morten A, Bonàs-Guarch Silvia, Holst Claus, Nohr Ellen A, Yadav Rachita, March Michael E, Blicher Thomas, Lackie Peter M, Jaddoe Vincent W V, Simpson Angela, Holloway John W, Duijts Liesbeth, Custovic Adnan, Davies Donna E, Torrents David, Gupta Ramneek, Hollegaard Mads V, Hougaard David M, Hakonarson Hakon, Bisgaard Hans
Abstract excerpt
Asthma exacerbations are among the most frequent causes of hospitalization during childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide association study of a specific asthma phenotype characterized by recurrent, severe exacerbations occurring between 2 and 6 years of age in a total of 1,173 cases and 2,522 controls. Cases were identified from national health registries of...
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