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Article

A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.

The Journal of allergy and clinical immunology - 1 Apr 2008

Tavendale Roger, Macgregor Donald F, Mukhopadhyay Somnath, Palmer Colin N A

Abstract excerpt

BACKGROUND: The specific genetic contributions to childhood asthma have been difficult to elucidate. A recent whole-genome association study suggested that single nucleotide polymorphisms at loci controlling the expression of the ORMDL3 gene and others in the neighborhood of the NRG1 and ERO1LB genes might be important. OBJECTIVE: We sought to replicate the associations of these genetic markers with asthma in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18395550
DOI: 10.1016/j.jaci.2008.01.015

Genes

ORMDL3
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.PMID 18395550Read ↗

Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population.Semantic proximity Read ↗

Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma.Semantic proximity Read ↗

ORMDL3 gene is associated with asthma in three ethnically diverse populations.Semantic proximity Read ↗

Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact.Semantic proximity Read ↗

Genetic variation in ORMDL3 gene may contribute to the risk of asthma: a meta-analysis.Semantic proximity Read ↗

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.Semantic proximity Read ↗

Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation.Semantic proximity Read ↗

ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestrySemantic proximity Read ↗

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.Semantic proximity Read ↗

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.Semantic proximity Read ↗

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Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.Semantic proximity Read ↗

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