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Article

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.

Nature immunology - 29 Apr 2012

Takahashi Hayato, Kanno Tomohiko, Nakayamada Shingo, Hirahara Kiyoshi, Sciumè Giuseppe, Muljo Stefan A, Kuchen Stefan, Casellas Rafael, Wei Lai, Kanno Yuka, O'Shea John J

Abstract excerpt

Distinct CD4(+) T cell subsets are critical for host defense and immunoregulation. Although these subsets can act as terminally differentiated lineages, they have been increasingly noted to demonstrated plasticity. MicroRNAs are factors that control T cell stability and plasticity. Here we report that naturally occurring regulatory T cells (T(reg) cells) had high expression of the microRNA miR-10a and that...

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Identifiers

PMID: 22544395
DOI: 10.1038/ni.2286
PMCID: PMC3499969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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