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Article

Absolute quantification of somatic DNA alterations in human cancer.

Nature biotechnology - 1 May 2012

Carter Scott L, Cibulskis Kristian, Helman Elena, McKenna Aaron, Shen Hui, Zack Travis, Laird Peter W, Onofrio Robert C, Winckler Wendy, Weir Barbara A, Beroukhim Rameen, Pellman David, Levine Douglas A, Lander Eric S, Meyerson Matthew, Getz Gad

Abstract excerpt

We describe a computational method that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations. The method, named ABSOLUTE, can detect subclonal heterogeneity and somatic homozygosity, and it can calculate statistical sensitivity for detection of specific aberrations. We used ABSOLUTE to analyze exome sequencing data from 214 ovarian carcinoma tumor-normal pairs. This...

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Identifiers

PMID: 22544022
DOI: 10.1038/nbt.2203
PMCID: PMC4383288

Genes

CDK12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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