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Article

TPES: tumor purity estimation from SNVs

8 May 2019

Abstract excerpt

MOTIVATION: Tumor purity (TP) is the proportion of cancer cells in a tumor sample. TP impacts on the accurate assessment of molecular and genomics features as assayed with NGS approaches. State-of-the-art tools mainly rely on somatic copy-number alterations (SCNA) to quantify TP and therefore fail when a tumor genome is nearly euploid, i.e. 'non-aberrant' in terms of identifiable SCNAs. RESULTS: We introduce a...

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PMID: 31099386
DOI: 10.1093/bioinformatics/btz406

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