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Article

BACOM2.0 facilitates absolute normalization and quantification of somatic copy number alterations in heterogeneous tumor.

Scientific reports - 9 Sept 2015

Fu Yi, Yu Guoqiang, Levine Douglas A, Wang Niya, Shih Ie-Ming, Zhang Zhen, Clarke Robert, Wang Yue

Abstract excerpt

Most published copy number datasets on solid tumors were obtained from specimens comprised of mixed cell populations, for which the varying tumor-stroma proportions are unknown or unreported. The inability to correct for signal mixing represents a major limitation on the use of these datasets for subsequent analyses, such as discerning deletion types or detecting driver aberrations. We describe the BACOM2.0...

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Identifiers

PMID: 26350498
DOI: 10.1038/srep13955
PMCID: PMC4563570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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