Article
Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study.
PloS one - 1 Jan 2012
Buyske Steven, Wu Ying, Carty Cara L, Cheng Iona, Assimes Themistocles L, Dumitrescu Logan, Hindorff Lucia A, Mitchell Sabrina, Ambite Jose Luis, Boerwinkle Eric, Buzkova Petra, Carlson Chris S, Cochran Barbara, Duggan David, Eaton Charles B, Fesinmeyer Megan D, Franceschini Nora, Haessler Jeffrey, Jenny Nancy, Kang Hyun Min, Kooperberg Charles, Lin Yi, Le Marchand Loic, Matise Tara C, Robinson Jennifer G, Rodriguez Carlos, Schumacher Fredrick R, Voight Benjamin F, Young Alicia, Manolio Teri A, Mohlke Karen L, Haiman Christopher A, Peters Ulrike, Crawford Dana C, North Kari E
Abstract excerpt
The Metabochip is a custom genotyping array designed for replication and fine mapping of metabolic, cardiovascular, and anthropometric trait loci and includes low frequency variation content identified from the 1000 Genomes Project. It has 196,725 SNPs concentrated in 257 genomic regions. We evaluated the Metabochip in 5,863 African Americans; 89% of all SNPs passed rigorous quality control with a call rate of...
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