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Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study.

Circulation. Cardiovascular genetics - 1 Aug 2010

Keebler Mary E, Deo Rahul C, Surti Aarti, Konieczkowski David, Guiducci Candace, Burtt Noel, Buxbaum Sarah G, Sarpong Daniel F, Steffes Michael W, Wilson James G, Taylor Herman A, Kathiresan Sekar

Abstract excerpt

BACKGROUND: Genome-wide association studies in cohorts of European descent have identified novel genomic regions as associated with lipids, but their relevance in African Americans remains unclear. METHODS AND RESULTS: We genotyped 8 index single nucleotide polymorphisms (SNPs) and 488 tagging SNPs across 8 novel lipid loci in the Jackson Heart Study, a community-based cohort of 4605 African Americans. For each...

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Black or African American
Chromosome Mapping
Genetic Loci
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Lipid Metabolism

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Open in PubMed Open full text

Identifiers

PMID: 20570916
DOI: 10.1161/CIRCGENETICS.109.914267
PMCID: PMC3074173

Genes

ANGPTL3
DOCK7
GCKR

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