Article
Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration.
Journal of lipid research - 1 Sept 2015
Lanktree Matthew B, Elbers Clara C, Li Yun, Zhang Guosheng, Duan Qing, Karczewski Konrad J, Guo Yiran, Tragante Vinicius, North Kari E, Cushman Mary, Asselbergs Folkert W, Wilson James G, Lange Leslie A, Drenos Fotios, Reiner Alex P, Barnes Michael R, Keating Brendan J
Abstract excerpt
Meta-analyses of European populations has successfully identified genetic variants in over 150 loci associated with lipid levels, but results from additional ethnicities remain limited. Previously, we reported two novel lipid loci identified in a sample of 7,657 African Americans using a gene-centric array including 50,000 SNPs in 2,100 candidate genes. Initial discovery and follow-up of signals with P < 10(-5)...
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