Article
Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol.
Circulation. Cardiovascular genetics - 1 Apr 2011
Edmondson Andrew C, Braund Peter S, Stylianou Ioannis M, Khera Amit V, Nelson Christopher P, Wolfe Megan L, Derohannessian Stephanie L, Keating Brendan J, Qu Liming, He Jing, Tobin Martin D, Tomaszewski Maciej, Baumert Jens, Klopp Norman, Döring Angela, Thorand Barbara, Li Mingyao, Reilly Muredach P, Koenig Wolfgang, Samani Nilesh J, Rader Daniel J
Abstract excerpt
BACKGROUND: Plasma levels of high-density lipoprotein cholesterol (HDL-C) are known to be heritable, but only a fraction of the heritability is explained. We used a high-density genotyping array containing single-nucleotide polymorphisms (SNPs) from HDL-C candidate genes selected on known biology of HDL-C metabolism, mouse genetic studies, and human genetic association studies. SNP selection was based on tagging...
Topics
- Adult
- Aged
- Case-Control Studies
- Cholesterol, HDL
- Cohort Studies
- Delta-5 Fatty Acid Desaturase
- Female
- Genetic Loci
- Genome-Wide Association Study