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Article

Replication and fine-mapping of genetic predictors of lipid traits in African-Americans.

Journal of human genetics - 1 Oct 2017

Feng QiPing, Wei Wei-Qi, Levinson Rebecca T, Mosley Jonathan D, Stein C Michael

Abstract excerpt

Circulating lipid concentrations are among the strongest modifiable risk factors for coronary artery disease (CAD). Most genetic studies have focused on Caucasian populations with little information available for populations of African ancestry. Using a cohort of ~2800 African-Americans (AAs) from a biobank at Vanderbilt University (BioVU), we sought to trans-ethnically replicate genetic variants reported by the...

Topics

Adult
Black or African American
Alleles
Biomarkers
Chromosome Mapping
Female
Genetic Association Studies
Genetics, Population
Genotype
High-Throughput Nucleotide Sequencing
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inheritance Patterns

Lipids

Male

Middle Aged

Phenotype

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 28539666
DOI: 10.1038/jhg.2017.55
PMCID: PMC5612856

Genes

APOE
CETP
LDLR
APOC1
CAD
CELSR2
LPL
PCSK9
SORT1
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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