Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.

doi:10.1371/journal.pone.0113203

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Article

Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.

PloS one - 1 Jan 2014

Franceschini Nora, Hu Yijuan, Reiner Alex P, Buyske Steven, Nalls Mike, Yanek Lisa R, Li Yun, Hindorff Lucia A, Cole Shelley A, Howard Barbara V, Stafford Jeanette M, Carty Cara L, Sethupathy Praveen, Martin Lisa W, Lin Dan-Yu, Johnson Karen C, Becker Lewis C, North Kari E, Dehghan Abbas, Bis Joshua C, Liu Yongmei, Greenland Philip, Manson JoAnn E, Maeda Nobuyo, Garcia Melissa, Harris Tamara B, Becker Diane M, O'Donnell Christopher, Heiss Gerardo, Kooperberg Charles, Boerwinkle Eric

Abstract excerpt

BACKGROUND: Coronary heart disease (CHD) is a leading cause of morbidity and mortality in African Americans. However, there is a paucity of studies assessing genetic determinants of CHD in African Americans. We examined the association of published variants in CHD loci with incident CHD, attempted to fine map these loci, and characterize novel variants influencing CHD risk in African Americans. METHODS AND...

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PMID: 25542012
DOI: 10.1371/journal.pone.0113203
PMCID: PMC4277270

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