Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.

doi:10.1038/s41467-018-05747-8

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Article

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.

Nature communications - 23 Aug 2018

Natarajan Pradeep, Peloso Gina M, Zekavat Seyedeh Maryam, Montasser May, Ganna Andrea, Chaffin Mark, Khera Amit V, Zhou Wei, Bloom Jonathan M, Engreitz Jesse M, Ernst Jason, O'Connell Jeffrey R, Ruotsalainen Sanni E, Alver Maris, Manichaikul Ani, Johnson W Craig, Perry James A, Poterba Timothy, Seed Cotton, Surakka Ida L, Esko Tonu, Ripatti Samuli, Salomaa Veikko, Correa Adolfo, Vasan Ramachandran S, Kellis Manolis, Neale Benjamin M, Lander Eric S, Abecasis Goncalo, Mitchell Braxton, Rich Stephen S, Wilson James G, Cupples L Adrienne, Rotter Jerome I, Willer Cristen J, Kathiresan Sekar

Abstract excerpt

Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative traits-plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and triglycerides. Common variant association yields...

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Identifiers

PMID: 30140000
DOI: 10.1038/s41467-018-05747-8
PMCID: PMC6107638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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