Article
A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans.
PloS one - 1 Jan 2019
Pendergrass Sarah A, Buyske Steven, Jeff Janina M, Frase Alex, Dudek Scott, Bradford Yuki, Ambite Jose-Luis, Avery Christy L, Buzkova Petra, Deelman Ewa, Fesinmeyer Megan D, Haiman Christopher, Heiss Gerardo, Hindorff Lucia A, Hsu Chun-Nan, Jackson Rebecca D, Lin Yi, Le Marchand Loic, Matise Tara C, Monroe Kristine R, Moreland Larry, North Kari E, Park Sungshim L, Reiner Alex, Wallace Robert, Wilkens Lynne R, Kooperberg Charles, Ritchie Marylyn D, Crawford Dana C
Abstract excerpt
We performed a hypothesis-generating phenome-wide association study (PheWAS) to identify and characterize cross-phenotype associations, where one SNP is associated with two or more phenotypes, between thousands of genetic variants assayed on the Metabochip and hundreds of phenotypes in 5,897 African Americans as part of the Population Architecture using Genomics and Epidemiology (PAGE) I study. The PAGE I study...
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