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Article

Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.

Nature - 22 Apr 2004

Webster Sarah M, Del Camino Donato, Dekker John P, Yellen Gary

Abstract excerpt

Voltage-gated potassium channels such as Shaker help to control electrical signalling in neurons by regulating the passage of K+ across cell membranes. Ion flow is controlled by a voltage-dependent gate at the intracellular side of the pore, formed by the crossing of four alpha-helices--the inner-pore helices. The prevailing model of gating is based on a comparison of the crystal structures of two bacterial...

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Identifiers

PMID: 15103379
DOI: 10.1038/nature02468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.PMID 15103379Read ↗

Atomic proximity between S4 segment and pore domain in Shaker potassium channels.Semantic proximity Read ↗

Potassium channel opening: a subtle two-step.Semantic proximity Read ↗

Tracking a complete voltage-sensor cycle with metal-ion bridges.Semantic proximity Read ↗

Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.Semantic proximity Read ↗

Gating of shaker-type channels requires the flexibility of S6 caused by prolines.Semantic proximity Read ↗

Tail end of the s6 segment: role in permeation in shaker potassium channels.Semantic proximity Read ↗

Gated access to the pore of a voltage-dependent K+ channel.Semantic proximity Read ↗

Role of hydrophobic and ionic forces in the movement of S4 of the Shaker potassium channel.Semantic proximity Read ↗

Closed state structure of the pore revealed by uncoupled Shaker K+ channel.Semantic proximity Read ↗

Conformational dynamics of the inner pore helix of voltage-gated potassium channels.Semantic proximity Read ↗

The pore structure and gating mechanism of K2P channels.Semantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

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