Potassium channel opening: a subtle two-step.

Abstract excerpt

Voltage-gated K(+) channels undergo a voltage-dependent conductance change that plays a key role in modulating cellular excitability. While the Open state is captured in crystal structures of Kv1.2 and a chimeric Kv1.2/Kv2.1 channel, the Close state and the mechanism of this transition are still a subject of debate. Here, we propose a model based on mutagenesis combined with measurements of both ionic and gating...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Crystallization
• Share to Amino Acid Sequence
• Share to Ion Channel Gating