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Article

Convergence of genetic influences in comorbidity.

BMC bioinformatics - 13 Mar 2012

McEachin Richard C, Sannareddy Keerthi S, Cavalcoli James D, Karnovsky Alla, Vink Jacqueline M, Sartor Maureen A

Abstract excerpt

BACKGROUND: Predisposition to complex diseases is explained in part by genetic variation, and complex diseases are frequently comorbid, consistent with pleiotropic genetic variation influencing comorbidity. Genome Wide Association (GWA) studies typically assess association between SNPs and a single-disease phenotype. Fisher meta-analysis combines evidence of association from single-disease GWA studies, assuming...

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Share to Linkage Disequilibrium
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Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22536871
DOI: 10.1186/1471-2105-13-S2-S8
PMCID: PMC3375629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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