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Article

SCN1A affects brain structure and the neural activity of the aging brain.

Biological psychiatry - 15 Oct 2012

Meier Sandra, Demirakca Traute, Brusniak Wencke, Wolf Isabella, Liebsch Kristin, Tunc-Skarka Nuran, Nieratschker Vanessa, Witt Stephanie H, Matthäus Franziska, Ende Gabriele, Flor Herta, Rietschel Marcella, Diener Carsten, Schulze Thomas G

Abstract excerpt

BACKGROUND: The aging of the human brain is accompanied by changes in cortical structure as well as functional activity and variable degrees of cognitive decline. One-third of the observable inter-individual differences in cognitive decline are thought to be heritable. SCN1A encodes the sodium channel α subunit and is considered to be a susceptibility gene for several neurological disorders with prominent...

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Identifiers

PMID: 22534457
DOI: 10.1016/j.biopsych.2012.03.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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