Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol.

doi:10.1002/nbm.3057

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Article

Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol.

NMR in biomedicine - 1 Feb 2014

Tunc-Skarka Nuran, Meier Sandra, Demirakca Traute, Sack Markus, Weber-Fahr Wolfgang, Brusniak Wencke, Wolf Isabella, Matthäus Franziska, Schulze Thomas G, Diener Carsten, Ende Gabriele

Abstract excerpt

Previously reported MRS findings in the aging brain include lower N-acetylaspartate (NAA) and higher myo-inositol (mI), total creatine (Cr) and choline-containing compound (Cho) concentrations. Alterations in the sodium channel voltage gated type I, alpha subunit SCN1A variant rs10930201 have been reported to be associated with several neurological disorders with cognitive deficits. MRS studies in SCN1A-related...

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PMID: 24357141
DOI: 10.1002/nbm.3057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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