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Article

Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2025

Laurell Axel A S, Mak Elijah, Dounavi Maria-Eleni, Underwood Benjamin R, Dauvilliers Yves, Dudas Robert B, Marguet Oriane, Ritchie Craig W, Koychev Ivan, Lawlor Brian A, Naci Lorina, Malhotra Paresh, Grau-Rivera Oriol, Gispert Juan Domingo, O'Brien John T

Abstract excerpt

INTRODUCTION: Sleep dysfunction in those at higher risk of dementia may be associated with early structural changes to the hypothalamus. METHODS: We used multivariate regression to analyze self-reported sleep (Pittsburgh Sleep Quality Index [PSQI]) from cognitively healthy participants in the PREVENT Dementia and Alzheimer's and Families (ALFA) studies (n = 1939), stratified by apolipoprotein E (APOE) genotype as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40356022
DOI: 10.1002/alz.70244
PMCID: PMC12069023

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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