Association of APOE rs405509 (-219 T/G) with multidimensional cognitive function, brain structure, and resting-state networks in Chinese community-dwelling older adults.

doi:10.1016/j.brainresbull.2026.112017

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Article

Association of APOE rs405509 (-219 T/G) with multidimensional cognitive function, brain structure, and resting-state networks in Chinese community-dwelling older adults.

Brain research bulletin - 1 Sept 2026

Wang Zhiyuan, Ding Jian, Hu Xuejie, Bai Ju, Li Jianshuai, Pang Jinchao, Ren Lianjie, Dong Mengxiao, Wang Lei, Sun Jinping

Abstract excerpt

BACKGROUND: The effects of the APOE rs405509 (-219 T/G) polymorphism on cognition, lipid profiles, gray matter volume (GMV), and resting-state networks (RSNs) in older Chinese adults remain unclear. METHODS: A total of 123 community-dwelling elderly individuals were divided into G allele carriers (n = 68) and TT homozygotes (n = 55). Participants underwent neuropsychological assessments and lipid detection; 111...

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PMID: 42336159
DOI: 10.1016/j.brainresbull.2026.112017

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