Article
Lack of association between GTF2H4 genetic variants and AERD development and FEV1 decline by aspirin provocation.
International journal of immunogenetics - 1 Dec 2012
Kim J Y, Kim J-H, Bae J S, Park B-L, Uh S-T, Kim M-K, Choi I S, Cho S H, Park C-S, Shin H D
Abstract excerpt
Aspirin-exacerbated respiratory disease (AERD) is prevalent in about 10% of asthma patients and is characterized by a severe decline in forced expiratory volume in 1-s (FEV(1) ), an important phenotype for total lung capacity, upon ingestion of aspirin. The general transcription factor IIH subunit 4 (GTF2H4) is positioned at 6p21.33, a part of the major histocompatibility complex (MHC) class II region that...
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