Article
Association of FANCC polymorphisms with FEV1 decline in aspirin exacerbated respiratory disease.
Molecular biology reports - 1 Mar 2012
Kim Jeong-Hyun, Park Byung-Lae, Pasaje Charisse Flerida A, Bae Joon Seol, Park Jong Sook, Park Sung Woo, Uh Soo-Taek, Choi Jae-Sung, Kim Yong-Hoon, Kim Mi-Kyeong, Choi Inseon S, Cho Sang Heon, Choi Byoung Whui, Park Choon-Sik, Shin Hyoung Doo
Abstract excerpt
Aspirin exacerbated respiratory disease (AERD) is a clinical condition characterized by severe decline in forced expiratory volume in one second (FEV1) following the ingestion of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin. The exacerbated inflammatory response in Fancc-deficient mice has been reported to be associated with hemopoietic responses that are also related to AERD pathogenesis. To...
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