Article
Potential association between ANXA4 polymorphisms and aspirin-exacerbated respiratory disease.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 2012
Park Tae-Joon, Kim Jeong-Hyun, Bae Joon Seol, Park Byung-Lae, Cheong Hyun Sub, Pasaje Charisse Flerida, Park Jong-Sook, Uh Soo-Taek, Kim Mi-Kyeong, Choi Inseon S, Park Choon-Sik, Shin Hyoung Doo
Abstract excerpt
Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by bronchoconstriction after ingestion of nonsteroidal anti-inflammatory drugs including aspirin. The Ca concentration in bronchial epithelial cells is an important factor for bronchoconstriction. Human annexin A4 (ANXA4) is predominantly expressed in the secretory epithelia in the lung, stomach, intestine, and kidney....
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