Article
Genetic variants of the gasdermin B gene associated with the development of aspirin-exacerbated respiratory diseases.
Allergy and asthma proceedings - 1 Jan 2017
Kim Lyoung Hyo, Chang HunSoo, Namgoong Suhg, Kim Ji On, Cheong Hyun Sub, Lee Seo-Gyeong, Park Jong Sook, Baek Ae Rin, Koo So-My, Choi Inseon S, Kim Mi-Kyeong, Park Hea-Sim, Park Choon-Sik, Shin Hyoung Doo
Abstract excerpt
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by a severe and sudden asthma attack after aspirin ingestion in patients with asthma. We studied associations with six common single nucleotide polymorphisms (SNP) of the gasdermin B gene (GSDMB). OBJECTIVE: DNA obtained from 572 patients with asthma (with AERD, n = 165; and with aspirin-tolerant asthma, n = 407) and 391 normal controls...
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