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Article

Association analysis of DTD1 gene variations with aspirin-intolerance in asthmatics.

International journal of molecular medicine - 1 Jul 2011

Pasaje Charisse Flerida A, Bae Joon Seol, Park Byung-Lae, Jang An-Soo, Uh Soo-Taek, Kim Mi-Kyeong, Koh In Song, Kim Jeong-Hyun, Park Tae-Joon, Lee Jin-Sol, Kim Yongha, Park Choon-Sik, Shin Hyoung Doo

Abstract excerpt

Aspirin ingestion is a common precipitating factor of life-threatening asthma attacks, requiring some patients to undergo mechanical ventilation. The gene, D-tyrosyl-tRNA deacylase 1 (DTD1), may be a risk factor for aspirin-intolerant asthma (AIA) by catalyzing the hydrolysis of D-tryptophan and interacting with the tyrosyl-tRNA synthetase (tyrRS) enzyme, which promotes a pro-inflammatory phenotype. In order to...

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Identifiers

PMID: 21479357
DOI: 10.3892/ijmm.2011.669

Genes

DTD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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