Article
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.
Annals of the rheumatic diseases - 1 Nov 2012
Kim Kwangwoo, Brown Elizabeth E, Choi Chan-Bum, Alarcón-Riquelme Marta E, Kelly Jennifer A, Glenn Stuart B, Ojwang Joshua O, Adler Adam, Lee Hye-Soon, Boackle Susan A, Criswell Lindsey A, Alarcón Graciela S, Edberg Jeffrey C, Stevens Anne M, Jacob Chaim O, Gilkeson Gary S, Kamen Diane L, Tsao Betty P, Anaya Juan-Manuel, Guthridge Joel M, Nath Swapan K, Richardson Bruce, Sawalha Amr H, Kang Young Mo, Shim Seung Cheol, Suh Chang-Hee, Lee Soo-Kon, Kim Chang-sik, Merrill Joan T, Petri Michelle, Ramsey-Goldman Rosalind, Vilá Luis M, Niewold Timothy B, Martin Javier, Pons-Estel Bernardo A, Vyse Timothy J, Freedman Barry I, Moser Kathy L, Gaffney Patrick M, Williams Adrienne, Comeau Mary, Reveille John D, James Judith A, Scofield R Hal, Langefeld Carl D, Kaufman Kenneth M, Harley John B, Kang Changwon, Kimberly Robert P, Bae Sang-Cheol
Abstract excerpt
OBJECTIVE: Systemic lupus erythematosus (SLE; OMIM 152700) is a chronic autoimmune disease for which the aetiology includes genetic and environmental factors. ITGAM, integrin α(M) (complement component 3 receptor 3 subunit) encoding a ligand for intracellular adhesion molecule (ICAM) proteins, is an established SLE susceptibility locus. This study aimed to evaluate the independent and joint effects of genetic...
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