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Article

The CD11b-integrin (ITGAM) and systemic lupus erythematosus.

Lupus - 1 Jun 2013

Fagerholm S C, MacPherson M, James M J, Sevier-Guy C, Lau C S

Abstract excerpt

Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 (alphaMbeta2; CD11b/CD18; complement receptor-3) integrin, is one of the strongest genetic risk factors for systemic lupus erythematosus (SLE). More specifically, a genetic variant (rs1143679) which results in an arginine to histidine substitution at position 77 in the extracellular portion of the integrin is associated with disease. It...

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Source

Identifiers

PMID: 23753600
DOI: 10.1177/0961203313491851

Genes

ITGAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The CD11b-integrin (ITGAM) and systemic lupus erythematosus.PMID 23753600Read ↗

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