A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

doi:10.1038/ng.71

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Article

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

Nature genetics - 1 Feb 2008

Nath Swapan K, Han Shizhong, Kim-Howard Xana, Kelly Jennifer A, Viswanathan Parvathi, Gilkeson Gary S, Chen Wei, Zhu Cheng, McEver Rodger P, Kimberly Robert P, Alarcón-Riquelme Marta E, Vyse Timothy J, Li Quan-Zhen, Wakeland Edward K, Merrill Joan T, James Judith A, Kaufman Kenneth M, Guthridge Joel M, Harley John B

Abstract excerpt

We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 x 10(-17), odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P...

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PMID: 18204448
DOI: 10.1038/ng.71

Genes

ITGAM

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A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.PMID 18204448Read ↗

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