ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.

doi:10.1136/ard.2009.120543

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Article

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.

Annals of the rheumatic diseases - 1 Jul 2010

Kim-Howard Xana, Maiti Amit K, Anaya Juan-Manuel, Bruner Gail R, Brown Elizabeth, Merrill Joan T, Edberg Jeffrey C, Petri Michelle A, Reveille John D, Ramsey-Goldman Rosalind, Alarcon Graciela S, Vyse Timothy J, Gilkeson Gary, Kimberly Robert P, James Judith A, Guthridge Joel M, Harley John B, Nath Swapan K

Abstract excerpt

PURPOSE: It was hypothesised that the coding variant (R77H), rs1143679, within ITGAM could predict specific clinical manifestations associated with systemic lupus erythematosus (SLE). METHOD: To assess genetic association, 2366 patients with SLE and 2931 unaffected controls with European ancestry were analysed. The patients with SLE were coded by the presence or absence of individual American College of...

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PMID: 19939855
DOI: 10.1136/ard.2009.120543
PMCID: PMC2891778

Genes

ITGAM

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ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.PMID 19939855Read ↗

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