Article
ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.
Annals of the rheumatic diseases - 1 Jul 2010
Kim-Howard Xana, Maiti Amit K, Anaya Juan-Manuel, Bruner Gail R, Brown Elizabeth, Merrill Joan T, Edberg Jeffrey C, Petri Michelle A, Reveille John D, Ramsey-Goldman Rosalind, Alarcon Graciela S, Vyse Timothy J, Gilkeson Gary, Kimberly Robert P, James Judith A, Guthridge Joel M, Harley John B, Nath Swapan K
Abstract excerpt
PURPOSE: It was hypothesised that the coding variant (R77H), rs1143679, within ITGAM could predict specific clinical manifestations associated with systemic lupus erythematosus (SLE). METHOD: To assess genetic association, 2366 patients with SLE and 2931 unaffected controls with European ancestry...
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