Article
Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).
Human molecular genetics - 15 Mar 2009
Han Shizhong, Kim-Howard Xana, Deshmukh Harshal, Kamatani Yoichiro, Viswanathan Parvathi, Guthridge Joel M, Thomas Kenaz, Kaufman Kenneth M, Ojwang Joshua, Rojas-Villarraga Adriana, Baca Vicente, Orozco Lorena, Rhodes Benjamin, Choi Chan-Bum, Gregersen Peter K, Merrill Joan T, James Judith A, Gaffney Patrick M, Moser Kathy L, Jacob Chaim O, Kimberly Robert P, Harley John B, Bae Sang-Choel, Anaya Juan-Manuel, Alarcón-Riquelme Marta E, Matsuda Koichi, Vyse Timothy J, Nath Swapan K
Abstract excerpt
We recently identified a novel non-synonymous variant, rs1143679, at exon 3 of the ITGAM gene associated with systemic lupus erythematosus (SLE) susceptibility in European-Americans (EAs) and African-Americans. Using genome-wide association approach, three other studies also independently reporte...
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