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Article

Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosus.

PloS one - 2 Dec 2010

Järvinen Tiina M, Hellquist Anna, Koskenmies Sari, Einarsdottir Elisabet, Panelius Jaana, Hasan Taina, Julkunen Heikki, Padyukov Leonid, Kvarnström Marika, Wahren-Herlenius Marie, Nyberg Filippa, D'Amato Mauro, Kere Juha, Saarialho-Kere Ulpu

Abstract excerpt

BACKGROUND: Lupus erythematosus (LE) is a heterogeneous disease ranging from mainly skin-restricted manifestations (discoid LE [DLE] and subacute cutaneous LE) to a progressive multisystem disease (systemic LE [SLE]). Genetic association studies have recently identified several strong susceptibil...

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Source

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Identifiers

PMID: 21151989
DOI: 10.1371/journal.pone.0014212
PMCID: PMC2996302

Genes

ITGAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21151989-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosus.PMID 21151989Read ↗

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.Semantic proximity Read ↗

Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus.Semantic proximity Read ↗

Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.Semantic proximity Read ↗

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.Semantic proximity Read ↗

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.Semantic proximity Read ↗

ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.Semantic proximity Read ↗

Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.Semantic proximity Read ↗

Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population.Semantic proximity Read ↗

ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico.Semantic proximity Read ↗

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.Semantic proximity Read ↗

Genetic association study of systemic lupus erythematosus and disease subphenotypes in European populations.Semantic proximity Read ↗

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