Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Indoleamine 2,3-dioxygenase expression and functional activity in dendritic cells exposed to cholera toxin.

Scandinavian journal of immunology - 1 Aug 2012

Slavica L, Nurkkala-Karlsson M, Karlson T, Ingelsten M, Nyström J, Eriksson K

Abstract excerpt

Indoleamine 2,3-dioxygenase (IDO), a tryptophan-metabolizing enzyme expressed by dendritic cells (DC), has the potential to inhibit T cell responses and to promote tolerance. In contrast, cholera toxin (CT), the enterotoxin produced by Vibrio cholerae, promotes T cell responses, partly through its ability to induce DC maturation and promote antigen presentation. We hypothesized that the adjuvant activity of CT is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to CD40 Ligand

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholera Toxin

Share to Dendritic Cells

Share to Gene Expression Regulation, Enzymologic

Share to Indoleamine-Pyrrole 2,3,-Dioxygenase

Share to Interleukin-12 Subunit p40

Share to Vibrio cholerae

Source

Identifiers

PMID: 22519828
DOI: 10.1111/j.1365-3083.2012.02713.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Indoleamine 2,3-dioxygenase expression and functional activity in dendritic cells exposed to cholera toxin.PMID 22519828Read ↗

Indoleamine 2,3-Dioxygenase and Dendritic Cell TolerogenicitySemantic proximity Read ↗

Cholera toxin impairs the differentiation of monocytes into dendritic cells, inducing professional antigen-presenting myeloid cells.Semantic proximity Read ↗

Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.Semantic proximity Read ↗

Human type 1 and type 2 conventional dendritic cells express indoleamine 2,3-dioxygenase 1 with functional effects on T cell priming.Semantic proximity Read ↗

Bordetella pertussis Commits Human Dendritic Cells to Promote a Th1/Th17 Response through the Activity of Adenylate Cyclase Toxin and MAPK-PathwaysSemantic proximity Read ↗

Functional and phenotypic effects of AhR activation in inflammatory dendritic cells.Semantic proximity Read ↗

The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells.Semantic proximity Read ↗

Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model.Semantic proximity Read ↗

Native and Genetically Inactivated Pertussis Toxins Induce Human Dendritic Cell Maturation and Synergize with Lipopolysaccharide in Promoting T Helper Type 1 ResponsesSemantic proximity Read ↗

Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients.Semantic proximity Read ↗

Tolerogenic Phenotype of IFN-γ-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO-Kynurenine/AhR-IDO Loop.Semantic proximity Read ↗

Normal development and function of dendritic cells in mice lacking IDO-1 expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.