Article
Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.
PloS one - 1 Jan 2017
Silva-Vilches Cinthia, Pletinckx Katrien, Lohnert Miriam, Pavlovic Vladimir, Ashour Diyaaeldin, John Vini, Vendelova Emilia, Kneitz Susanne, Zhou Jie, Chen Rena, Reinheckel Thomas, Mueller Thomas D, Bodem Jochen, Lutz Manfred B
Abstract excerpt
Immature or semi-mature dendritic cells (DCs) represent tolerogenic maturation stages that can convert naive T cells into Foxp3+ induced regulatory T cells (iTreg). Here we found that murine bone marrow-derived DCs (BM-DCs) treated with cholera toxin (CT) matured by up-regulating MHC-II and costimulatory molecules using either high or low doses of CT (CThi, CTlo) or with cAMP, a known mediator CT signals....
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