Article
Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model.
Arthritis research & therapy - 1 Jan 2008
Park Min-Jung, Min So-Youn, Park Kyung-Su, Cho Young-Gyu, Cho Mi-La, Jung Young-Ok, Park Hyun-Sil, Chang Soog-Hee, Cho Seok Goo, Min Jun-Ki, Park Sung-Hwan, Kim Ho-Youn
Abstract excerpt
INTRODUCTION: The present study was devised to understand the role of systemic indoleamine 2,3-dioxygenase (IDO) in the tolerance induction for orally tolerized mice in collagen-induced arthritis (CIA). We examined whether IDO-expressing dendritic cells (DCs) are involved in the generation of CD4+CD25+ regulatory T cells during the induction of oral tolerance in a murine CIA model. METHODS: Type II collagen was...
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