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Article

Normal development and function of dendritic cells in mice lacking IDO-1 expression.

Immunology letters - 15 Jun 2008

de Faudeur Geoffroy, de Trez Carl, Muraille Eric, Leo Oberdan

Abstract excerpt

Dendritic cells (DCs) have been shown to express the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO-1), a protein presently thought to exert dual and possibly contrasting effects on the immune response. Depletion of tryptophan and release of tryptophan catabolites have been shown to exert a tolerogenic influence on T cell responses, while the IDO enzymatic activity has been recently suggested to...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Indoleamine-Pyrrole 2,3,-Dioxygenase

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Share to Mice, Inbred BALB C

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Source

Identifiers

PMID: 18384884
DOI: 10.1016/j.imlet.2008.02.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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