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Article

Functional and phenotypic effects of AhR activation in inflammatory dendritic cells.

Toxicology and applied pharmacology - 1 Jul 2010

Bankoti Jaishree, Rase Ben, Simones Tom, Shepherd David M

Abstract excerpt

Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces immune suppression. Dendritic cells (DCs) are key antigen presenting cells governing T cell activation and differentiation. However, the consequences of AhR activation in DCs are not fully defined. We hypothesized that AhR activation alters DC differentiation and generates dysfunctional DCs. To test this hypothesis,...

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Share to Dendritic Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20350561
DOI: 10.1016/j.taap.2010.03.013
PMCID: PMC2885531

Genes

IDO1
IDO2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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