Article
Cholera toxin impairs the differentiation of monocytes into dendritic cells, inducing professional antigen-presenting myeloid cells.
Infection and immunity - 1 Mar 2011
Veglia Filippo, Sciaraffia Ester, Riccomi Antonella, Pinto Dora, Negri Donatella R M, De Magistris Maria Teresa, Vendetti Silvia
Abstract excerpt
Cholera toxin (CT) is a potent adjuvant for mucosal vaccination; however, its mechanism of action has not been clarified completely. It is well established that peripheral monocytes differentiate into dendritic cells (DCs) both in vitro and in vivo and that monocytes are the in vivo precursors of mucosal CD103(-) proinflammatory DCs. In this study, we asked whether CT had any effects on the differentiation of...
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