Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype.

Biomaterials - 1 Aug 2020

Barcellona Marcos N, Speer Julie E, Fearing Bailey V, Jing Liufang, Pathak Amit, Gupta Munish C, Buchowski Jacob M, Kelly Michael, Setton Lori A

Abstract excerpt

Cells of the nucleus pulposus have been observed to undergo a shift from their notochordal-like juvenile phenotype to a more fibroblast-like state with age and maturation. It has been demonstrated that culture of degenerative adult human nucleus pulposus cells upon soft (<1 kPa) full length laminin-containing hydrogel substrates promotes increased levels of a panel of markers associated with the juvenile nucleus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Intervertebral Disc
Share to Intervertebral Disc Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Laminin

Share to Ligands

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 32361392
DOI: 10.1016/j.biomaterials.2020.120057
PMCID: PMC7608136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype.PMID 32361392Read ↗

Integrin and syndecan binding peptide-conjugated alginate hydrogel for modulation of nucleus pulposus cell phenotype.Semantic proximity Read ↗

Engineered Peptide-Functionalized Hydrogels Modulate the RNA Transcriptome of Human Nucleus Pulposus Cells In VitroSemantic proximity Read ↗

Integrin-mediated interactions with a laminin-presenting substrate modulate biosynthesis and phenotypic expression for cells of the human nucleus pulposus.Semantic proximity Read ↗

Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration.Semantic proximity Read ↗

Substrate stiffness modulates gene expression and phenotype in neonatal cardiomyocytes in vitro.Semantic proximity Read ↗

Soft substrates drive optimal differentiation of human healthy and dystrophic myotubesSemantic proximity Read ↗

Inducing endoderm differentiation by modulating mechanical properties of soft substrates.Semantic proximity Read ↗

Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomaterials for Articular Cartilage Repair.Semantic proximity Read ↗

The stiffness-sensitive transcriptome of human tendon stromal cellsSemantic proximity Read ↗

Substrate stiffness induced mechanotransduction regulates temporal evolution of human fetal neural progenitor cell phenotype, differentiation, and biomechanics.Semantic proximity Read ↗

Cardiac myocytes respond differentially and synergistically to matrix stiffness and topographySemantic proximity Read ↗

Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.