Article
Mechanical and Electrical Phenotype of hiPSC-Cardiomyocytes on Fibronectin-Based Hydrogels.
Advanced healthcare materials - 1 Jul 2026
Costa Ana Da Silva, Stonkute Lineta, Trujillo Sara, Oliva Mariana Azevedo Gonzalez, Burton Francis, Dalby Matthew J, Dobre Oana, Smith Godfrey, Salmeron-Sanchez Manuel
Abstract excerpt
A major challenge in cardiac research is the limited translatability of drug screening and toxicity assays due to the use of in vitro models that poorly mimic the native cardiac environment. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer a promising route forward, but conventional 2D culture on rigid substrates hinders their functional maturation and predictive accuracy. This study...
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