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Article

Desert hedgehog links transcription factor Sox10 to perineurial development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Apr 2012

Küspert Melanie, Weider Matthias, Müller Jana, Hermans-Borgmeyer Irm, Meijer Dies, Wegner Michael

Abstract excerpt

Schwann cells are the main glial cell type in the PNS. They develop along nerves during embryogenesis and rely on the HMG domain containing Sox10 transcription factor for specification, lineage progression, and terminal differentiation. Sox10 deletion in immature Schwann cells caused peripheral nerve defects in mice that were not restricted to this glial cell type, although expression in the nerve and gene loss...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22514309
DOI: 10.1523/JNEUROSCI.5759-11.2012
PMCID: PMC6703490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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