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Article

SOX10 structure-function analysis in the chicken neural tube reveals important insights into its role in human neurocristopathies.

Human molecular genetics - 15 Jun 2010

Cossais François, Wahlbuhl Mandy, Kriesch Jana, Wegner Michael

Abstract excerpt

The HMG-domain containing transcription factor Sox10 is essential for neural crest (NC) development and for oligodendrocyte differentiation. Heterozygous SOX10 mutations in humans lead to corresponding defects in several NC-derived lineages and to leukodystrophies. Disease phenotypes range from Waardenburg syndrome and Waardenburg-Hirschsprung disease to Peripheral demyelinating neuropathy, Central...

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Source

Identifiers

PMID: 20308050
DOI: 10.1093/hmg/ddq124

Genes

SOX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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SOX10 structure-function analysis in the chicken neural tube reveals important insights into its role in human neurocristopathies.PMID 20308050Read ↗

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