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Article

Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.

Genes & development - 15 Jan 2002

Stolt C Claus, Rehberg Stephan, Ader Marius, Lommes Petra, Riethmacher Dieter, Schachner Melitta, Bartsch Udo, Wegner Michael

Abstract excerpt

Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural...

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Source

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Identifiers

PMID: 11799060
DOI: 10.1101/gad.215802
PMCID: PMC155320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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