Article
Genotype analysis of tumor-initiating cells expressing CD133 in neuroblastoma.
Genes, chromosomes & cancer - 1 Aug 2012
Cournoyer Sonia, Nyalendo Carine, Addioui Anissa, Belounis Assila, Beaunoyer Mona, Aumont Anne, Teira Pierre, Duval Michel, Fernandes Karl, Fetni Raouf, Haddad Elie, Sartelet Hervé
Abstract excerpt
Neuroblastoma (NB) is the most common and lethal extracranial solid tumor of childhood. Despite aggressive therapy, more than half of the children with advanced NB will die of uncontrolled metastatic disease. After chemotherapy, tumor-initiating cells (TICs) could persist, cause relapses and metastasis. The aim of this study is to demonstrate the tumor-initiating properties of CD133high NB cells and to identify...
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