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Article

Functional Sphere Profiling Reveals the Complexity of Neuroblastoma Tumor-Initiating Cell Model

1 Oct 2011

Abstract excerpt

Neuroblastoma (NB) is a neural crest-derived childhood tumor characterized by a remarkable phenotypic diversity, ranging from spontaneous regression to fatal metastatic disease. Although the cancer stem cell (CSC) model provides a trail to characterize the cells responsible for tumor onset, the NB tumor-initiating cell (TIC) has not been identified. In this study, the relevance of the CSC model in NB was...

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PMID: 22028624
DOI: 10.1593/neo.11800

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