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Cancer Stem Cells and Neuroblastoma: Characteristics and Therapeutic Targeting Options

19 Nov 2019

Abstract excerpt

The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced levels of drug transporters, enhanced DNA-damage repair mechanisms, and a quiescent state. Neuroblastoma (NB) is considered a neuroendocrine tumor and is the most...

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PMID: 31803140
DOI: 10.3389/fendo.2019.00782

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